Blar i NTNU Open på forfatter "Dichgans, Martin"

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    • Genome-wide analysis of 102,084 migraine cases identifies 123 risk loci and subtype-specific risk alleles 

      Hautakangas, Heidi; Winsvold, Bendik K S; Ruotsalainen, Sanni; Bjornsdottir, Gyda; Harder, Aster V. E.; Kogelman, Lisette J. A.; Thomas, Laurent; Noordam, Raymond; Benner, Christian; Gormley, Padhraig; Artto, Ville; Banasik, Karina; Bjornsdottir, Anna; Boomsma, Dorret I.; Brumpton, Ben Michael; Burgdorf, Kristoffer Sølvsten; Buring, Julie E.; Chalmer, Mona Ameri; de Boer, Irene; Dichgans, Martin; Erikstrup, Christian; Färkkilä, Markus; Gabrielsen, Maiken Elvestad; Ghanbari, Mohsen; Hagen, Knut; Häppölä, Paavo; Hottenga, Jouke-Jan; Hrafnsdottir, Maria G.; Hveem, Kristian; Johnsen, Marianne Bakke; Kähönen, Mika; Kristoffersen, Espen Saxhaug; Kurth, Tobias; Lehtimäki, Terho; Lighart, Lannie; Magnusson, Sigurdur H.; Malik, Rainer; Pedersen, Ole Birger; Pelzer, Nadine; Penninx, Brenda W. J. H.; Ran, Caroline; Ridker, Paul M.; Rosendaal, Frits Richard; Sigurdardottir, Gudrun R.; Skogholt, Anne Heidi; Sveinsson, Olafur A.; Thorgeirsson, Thorgeir E.; Ullum, Henrik; Zwart, John Anker Henrik (Peer reviewed; Journal article, 2022)
      Migraine affects over a billion individuals worldwide but its genetic underpinning remains largely unknown. Here, we performed a genome-wide association study of 102,084 migraine cases and 771,257 controls and identified ...

    • Mendelian randomization for studying the effects of perturbing drug targets 

      Gill, Dipender; Georgakis, Marios K.; Walker, Venexia M.; Schmidt, Amand F.; Gkatzionis, Apostolos; Freitag, Daniel F.; Finan, Chris; Hingorani, Aroon D.; Howson, Joanna M.M.; Burgess, Stephen; Swerdlow, Daniel I.; Davey Smith, George; Holmes, Michael V.; Dichgans, Martin; Scott, Robert A.; Zheng, Jie; Psaty, Bruce M.; Davies, Neil Martin (Peer reviewed; Journal article, 2021)
      Drugs whose targets have genetic evidence to support efficacy and safety are more likely to be approved after clinical development. In this paper, we provide an overview of how natural sequence variation in the genes that ...

    • New insights into the genetic etiology of Alzheimer's disease and related dementias 

      Bellenguez, Céline; Küçükali, Fahri; Jansen, Iris E.; Kleineidam, Luca; Moreno-Grau, Sonia; Amin, Najaf; Naj, Adam C.; Campos-Martin, Rafael; Grenier-Boley, Benjamin; Andrade, Victor; Holmans, Peter A.; Boland, Anne; Damotte, Vincent; van der Lee, Sven J.; Costa, Marcos R.; Kuulasmaa, Teemu; Yang, Qiong; de Rojas, Itziar; Bis, Joshua C.; Yaqub, Amber; Prokic, Ivana; Chapuis, Julien; Ahmad, Shahzad; Giedraitis, Vilmantas; Aarsland, Dag; Garcia-Gonzalez, Pablo; Abdelnour, Carla; Alarcón-Martín, Emilio; Alcolea, Daniel; Alegret, Montserrat; Alvarez, Ignacio; Álvarez, Victoria; Armstrong, Nicola J.; Tsolaki, Anthoula; Antúnez, Carmen; Appollonio, Ildebrando; Arcaro, Marina; Archetti, Silvana; Pastor, Alfonso Arias; Arosio, Beatrice; Athanasiu, Lavinia; Bailly, Henri; Banaj, Nerisa; Baquero, Miquel; Barral, Sandra; Beiser, Alexa; Pastor, Ana Belén; Below, Jennifer E.; Benchek, Penelope; Benussi, Luisa; Berr, Claudine; Besse, Céline; Bessi, Valentina; Binetti, Giuliano; Bizarro, Alessandra; Blesa, Rafael; Boada, Mercè; Boerwinkle, Eric; Borroni, Barbara; Boschi, Silvia; Bossù, Paola; Bråthen, Geir; Bressler, Jan; Bresner, Catherine; Brodaty, Henry; Brookes, Keeley J.; Brusco, Luis Ignacio; Buiza-Rueda, Dolores; Bûrger, Katharina; Burholt, Vanessa; Bush, William S.; Calero, Miguel; Cantwell, Laura B.; Chene, Geneviève; Chung, Jaeyoon; Cuccaro, Michael L.; Carracedo, Ángel; Cecchetti, Roberta; Cervera-Carles, Laura; Charbonnier, Camille; Chen, Hung-Hsin; Chillotti, Caterina; Ciccone, Simona; Claassen, Jurgen A H R; Clark, Christopher; Conti, Elisa; Corma-Gómez, Anaïs; Costantini, Emanuele; Custodero, Carlo; Daian, Delphine; Dalmasso, Maria Carolina; Daniele, Antonio; Dardiotis, Efthimios; Dartigues, Jean-François; de Deyn, Peter Paul; de Paiva Lopes, Katia; de Witte, Lot D.; Debette, Stéphanie; Deckert, Jürgen; Del Ser, Teodoro; Denning, Nicola; DeStefano, Anita; Dichgans, Martin; Diehl-Schmid, Janine; Diez-Fairen, Mónica; Rossi, Paolo Dionigi; Djurovic, Srdjan; Duron, Emmanuelle; Düzel, Emrah; Dufouil, Carole; Eiriksdottir, Gudny; Engelborghs, Sebastiaan; Escott-Price, Valentina; Espinosa, Ana; Ewers, Michael; Faber, Kelley M.; Fabrizio, Tagliavini; Nielsen, Sune Fallgaard; Fardo, David W.; Farotti, Lucia; Fenoglio, Chiara; Fernández-Fuertes, Marta; Ferrari, Raffaele; Ferreira, Catarina B.; Ferri, Evelyn; Fin, Bertrand; Fischer, Peter; Fladby, Tormod; Fließbach, Klaus; Fongang, Bernard; Fornage, Myriam; Fortea, Juan; Foroud, Tatiana M.; Fostinelli, Silvia; Fox, Nick C.; Franco-Macías, Emlio; Bullido, María J; Frank-García, Ana; Froelich, Lutz; Fulton-Howard, Brian; Galimberti, Daniela; García-Alberca, Jose Maria; García-González, Pablo; Garcia-Madrona, Sebastian; Garcia-Ribas, Guillermo; Ghidoni, Roberta; Giegling, Ina; Giorgio, Giaccone; Goate, Alison M.; Goldhardt, Oliver; Gomez-Fonseca, Duber; González-Pérez, Antonio; Graff, Caroline; Grande, Giulia; Green, Emma; Grimmer, Timo; Grünblatt, Edna; Grunin, Michelle; Gudnason, Vilmundur; Guetta-Baranes, Tamar; Haapasalo, Annakaisa; Hadjigeorgiou, Georgios; Haines, Jonathan L.; Hamilton-Nelson, Kara L.; Hampel, Harald; Hanon, Olivier; Hardy, John; Hartmann, Annette M.; Hausner, Lucrezia; Harwood, Janet; Heilmann-Heimbach, Stefanie; Helisalmi, Seppo; Heneka, Michael T.; Hernández, Isabel; Herrmann, Martin J.; Hoffmann, Per; Holmes, Clive; Holstege, Henne; Vilas, Raquel Huerto; Hulsman, Marc; Humphrey, Jack; Biessels, Geert Jan; Jian, Xueqiu; Johansson, Charlotte; Jun, Gyungah R.; Kastumata, Yuriko; Kauwe, John; Kehoe, Patrick G.; Kilander, Lena; Ståhlbom, Anne Kinhult; Kivipelto, Miia; Koivisto, Anne; Kornhuber, Johannes; Kosmidis, Mary H.; Kukull, Walter A.; Kuksa, Pavel P.; Kunkle, Brian W.; Kuzma, Amanda B.; Lage, Carmen; Laukka, Erika J.; Launer, Lenore; Lauria, Alessandra; Lee, Chien-Yueh; Lehtisalo, Jenni; Lerch, Ondrej; Lleó, Alberto; Longstreth, William; Lopez, Oscar; de Munain, Adolfo Lopez; Love, Seth; Löwemark, Malin; Luckcuck, Lauren; Lunetta, Kathryn L.; Ma, Yiyi; Macías, Juan; MacLeod, Catherine A.; Maier, Wolfgang; Mangialasche, Francesca; Spallazzi, Marco; Marquié, Marta; Marshall, Rachel; Martin, Eden R.; Montes, Angel Martín; Rodríguez, Carmen Martínez; Masullo, Carlo; Mayeux, Richard; Mead, Simon; Mecocci, Patrizia; Medina, Miguel; Meggy, Alun; Mehrabian, Shima; Mendoza, Silvia; Menéndez-González, Manuel; Mir, Pablo; Moebus, Susanne; Mol, Merel; Molina-Porcel, Laura; Montrreal, Laura; Morelli, Laura; Moreno, Fermin; Morgan, Kevin; Mosley, Thomas; Nöthen, Markus M.; Muchnik, Carolina; Mukherjee, Shubhabrata; Nacmias, Benedetta; Ngandu, Tiia; Nicolas, Gael; Nordestgaard, Børge G; Olaso, Robert; Orellana, Adelina; Orsini, Michela; Ortega, Gemma; Padovani, Alessandro; Paolo, Caffarra; Papenberg, Goran; Parnetti, Lucilla; Pasquier, Florence; Pastor, Pau; Peloso, Gina; Pérez-Cordón, Alba; Pérez-Tur, Jordi; Pericard, Pierre; Peters, Oliver; Pijnenburg, Yolande A L; Pineda, Juan A.; Piñol-Ripoll, Gerard; Pisanu, Claudia; Polak, Thomas; Popp, Julius; Posthuma, Danielle; Priller, Josef; Puerta, Raquel; Quenez, Olivier; Quintela, Inés; Thomassen, Jesper Qvist; Rábano, Alberto; Rainero, Innocenzo; Rajabli, Farid; Ramakers, Inez; Real, Luis M.; Reinders, Marcel J T; Reitz, Christiane; Reyes-Dumeyer, Dolly; Ridge, Perry; Riedel-Heller, Steffi; Riederer, Peter; Roberto, Natalia; Rodriguez-Rodriguez, Eloy; Rongve, Arvid; Allende, Irene Rosas; Rosende-Roca, Maitée; Royo, Jose Luis; Rubino, Elisa; Rujescu, Dan; Sáez, María Eugenia; Sakka, Paraskevi; Saltvedt, Ingvild; Sanabria, Ángela; Sánchez-Arjona, María Bernal; Sanchez-Garcia, Florentino; Juan, Pascual Sánchez; Sánchez-Valle, Raquel; Sando, Sigrid Botne; Sarnowski, Chloé; Satizabal, Claudia L.; Scamosci, Michela; Scarmeas, Nikolaos; Scarpini, Elio; Scheltens, Philip; Scherbaum, Norbert; Scherer, Martin; Schmid, Matthias; Schneider, Anja; Schott, Jonathan M.; Selbæk, Geir; Seripa, Davide; Serrano, Manuel; Sha, Jin; Shadrin, Alexey; Skrobot, Olivia; Slifer, Susan; Snijders, Gijsje J L; Soininen, Hilkka; Solfrizzi, Vincenzo; Solomon, Alina; Song, Yeunjoo; Sorbi, Sandro; Sotolongo-Grau, Oscar; Spalletta, Gianfranco; Spottke, Annika; Squassina, Alessio; Stordal, Eystein; Tartan, Juan Pablo; Tárraga, Lluís; Tesí, Niccolo; Thalamuthu, Anbupalam; Thomas, Tegos; Tosto, Giuseppe; Traykov, Latchezar; Tremolizzo, Lucio; Tybjærg-Hansen, Anne; Uitterlinden, Andre; Ullgren, Abbe; Ulstein, Ingun; Valero, Sergi; Valladares, Otto; Broeckhoven, Christine Van; Vance, Jeffery; Vardarajan, Badri N.; van der Lugt, Aad; Dongen, Jasper Van; van Rooij, Jeroen; van Swieten, John; Vandenberghe, Rik; Verhey, Frans; Vidal, Jean-Sébastien; Vogelgsang, Jonathan; Vyhnalek, Martin; Wagner, Michael; Wallon, David; Wang, Li-San; Wang, Ruiqi; Weinhold, Leonie; Wiltfang, Jens; Windle, Gill; Woods, Bob; Yannakoulia, Mary; Zare, Habil; Zhao, Yi; Zhang, Xiaoling; Zhu, Congcong; Zulaica, Miren; Farrer, Lindsay A.; Psaty, Bruce M.; Ghanbari, Mohsen; Raj, Towfique; Sachdev, Perminder; Mather, Karen; Jessen, Frank; Ikram, M Arfan; de Mendonça, Alexandre; Hort, Jakub; Tsolaki, Magda; Pericak-Vance, Margaret A.; Amouyel, Philippe; Williams, Julie; Frikke-Schmidt, Ruth; Clarimon, Jordi; Deleuze, Jean-François; Rossi, Giacomina; Seshadri, Sudha; Andreassen, Ole; Ingelsson, Martin; Hiltunen, Mikko; Sleegers, Kristel; Schellenberg, Gerard D.; van Duijn, Cornelia M.; Sims, Rebecca; van der Flier, Wiesje M.; Ruiz, Agustín; Ramirez, Alfredo; Lambert, Jean-Charles (Peer reviewed; Journal article, 2022)
      Characterization of the genetic landscape of Alzheimer’s disease (AD) and related dementias (ADD) provides a unique opportunity for a better understanding of the associated pathophysiological processes. We performed a ...

    • Relationship between Blood Pressure and Incident Cardiovascular Disease: Linear and Nonlinear Mendelian Randomization Analyses 

      Malik, Rainer; Georgakis, Marios K.; Vujkovic, Marijana; Damrauer, Scott M.; Elliott, Paul; Karhunen, Ville; Giontella, Alice; Fava, Cristiano; Hellwege, Jacklyn N.; Shuey, Megan M.; Edwards, Todd L.; Rogne, Tormod; Åsvold, Bjørn Olav; Brumpton, Ben Michael; Burgess, Stephen; Dichgans, Martin; Gill, Dipender (Peer reviewed; Journal article, 2021)
      Observational studies exploring whether there is a nonlinear effect of blood pressure on cardiovascular disease (CVD) risk are hindered by confounding. This limitation can be overcome by leveraging randomly allocated genetic ...

    • Stroke genetics informs drug discovery and risk prediction across ancestries 

      Mishra, Aniket; Malik, Rainer; Hachiya, Tsuyoshi; Jürgenson, Tuuli; Namba, Shinichi; Posner, Daniel C.; Kamanu, Frederick K.; Koido, Masaru; Le Grand, Quentin; Shi, Mingyang; He, Yunye; Georgakis, Marios K.; Caro, Ilana; Krebs, Kristine; Liaw, Yi-Ching; Vaura, Felix C.; Lin, Kuang; Winsvold, Bendik K S; Srinivasasainagendra, Vinodh; Parodi, Livia; Bae, Hee-Joon; Chauhan, Ganesh; Tomppo, Liisa; Akinyemi, Rufus; Roshchupkin, Gennady V.; Habib, Naomi; Jee, Yon Ho; Thomassen, Jesper Qvist; Abedi, Vida; Cárcel-Márquez, Jara; Nygaard, Marianne; Leonard, Hampton L.; Yang, Chaojie; Yonova-Doing, Ekaterina; Knol, Maria J.; Lewis, Adam J.; Judy, Renae L.; Ago, Tetsuro; Amouyel, Philippe; Armstrong, Nicole D.; Bakker, Mark K.; Bartz, Traci M.; Bennett, David A.; Bis, Joshua C.; Bordes, Constance; Børte, Sigrid; Cain, Anael; Ridker, Paul M.; Cho, Kelly; Chen, Zhengming; Cruchaga, Carlos; Cole, John W.; de Jager, Phil L.; de Cid, Rafael; Endres, Matthias; Ferreira, Leslie E.; Geerlings, Mirjam I.; Gasca, Natalie C.; Gudnason, Vilmundur; Hata, Jun; He, Jing; Heath, Alicia K.; Ho, Yuk-Lam; Havulinna, Aki S.; Hopewell, Jemma C.; Hyacinth, Hyacinth I.; Inouye, Michael; Jacob, Mina A.; Jeon, Christina E.; Jern, Christina; Kamouchi, Masahiro; Keene, Keith L.; Kitazono, Takanari; Kittner, Steven J.; Konuma, Takahiro; Kumar, Amit; Lacaze, Paul; Launer, Lenore J.; Lee, Keon-Joo; Lepik, Kaido; Li, Jiang; Li, Liming; Manichaikul, Ani; Markus, Hugh S.; Marston, Nicholas A.; Meitinger, Thomas; Mitchell, Braxton D.; Montellano, Felipe A.; Morisaki, Takayuki; Mosley, Thomas H.; Nalls, Mike A.; Nordestgaard, Børge G; O'Donnell, Martin J.; Okada, Yukinori; Onland-Moret, N Charlotte; Ovbiagele, Bruce; Peters, Annette; Psaty, Bruce M.; Rich, Stephen S.; Rosand, Jonathan; Sabatine, Marc S.; Sacco, Ralph L.; Saleheen, Danish; Sandset, Else Charlotte; Salomaa, Veikko; Sargurupremraj, Muralidharan; Sasaki, Makoto; Satizabal, Claudia L.; Schmidt, Carsten O.; Shimizu, Atsushi; Smith, Nicholas L.; Sloane, Kelly L.; Sutoh, Yoichi; Sun, Yan V.; Tanno, Kozo; Tiedt, Steffen; Tatlisumak, Turgut; Torres-Aguila, Nuria P.; Tiwari, Hemant K.; Trégouët, David-Alexandre; Trompet, Stella; Tuladhar, Anil Man; Tybjærg-Hansen, Anne; van Vugt, Marion; Vibo, Riina; Verma, Shefali S.; Wiggins, Kerri L.; Wennberg, Patrik; Woo, Daniel; Wilson, Peter W F; Xu, Huichun; Yang, Qiong; Yoon, Kyungheon; Millwood, Iona Y.; Gieger, Christian; Ninomiya, Toshiharu; Grabe, Hans J.; Jukema, J Wouter; Rissanen, Ina L.; Strbian, Daniel; Kim, Young Jin; Chen, Pei-Hsin; Mayerhofer, Ernst; Howson, Joanna M M; Irvin, Marguerite R.; Adams, Hieab; Wassertheil-Smoller, Sylvia; Christensen, Kaare; Ikram, Mohammad A.; Rundek, Tatjana; Worrall, Bradford B.; Lathrop, G Mark; Riaz, Moeen; Simonsick, Eleanor M.; Kõrv, Janika; França, Paulo H C; Zand, Ramin; Prasad, Kameshwar; Frikke-Schmidt, Ruth; de Leeuw, Frank-Erik; Liman, Thomas; Haeusler, Karl Georg; Ruigrok, Ynte M.; Heuschmann, Peter Ulrich; Longstreth, W.T.; Jung, Keum Ji; Bastarache, Lisa; Paré, Guillaume; Damrauer, Scott M.; Chasman, Daniel I.; Rotter, Jerome I.; Anderson, Christopher D.; Zwart, John Anker Henrik; Niiranen, Teemu J.; Fornage, Myriam; Liaw, Yung-Po; Seshadri, Sudha; Fernández-Cadenas, Israel; Walters, Robin G.; Ruff, Christian T.; Owolabi, Mayowa O.; Huffman, Jennifer E.; Milani, Lili; Kamatani, Yoichiro; Dichgans, Martin; Debette, Stephanie (Peer reviewed; Journal article, 2022)
      Previous genome-wide association studies (GWASs) of stroke — the second leading cause of death worldwide — were conducted predominantly in populations of European ancestry1,2. Here, in cross-ancestry GWAS meta-analyses of ...